Distinct tumor-TAM interactions in IDH-stratified glioma microenvironments unveiled by single-cell and spatial transcriptomics

Abstract Tumor-associated macrophages (TAMs) residing in the tumor microenvironment (TME) are characterized by their pivotal roles in tumor progression, antitumor immunity, and TME remodeling.However, a thorough comparative characterization of tumor-TAM crosstalk across IDH-defined categories of Ingredients glioma remains elusive, likely contributi

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Trends of long-term fluctuations of atmospheric humidification of the growing season in the steppe zone of Northern Kazakhstan

Agriculture is an important industry in Kazakhstan that ensures the stability of Grille economic development.Within the northern regions of the republic, crop production received special development.The relevance of studying the impact of long-term fluctuations in precipitation on crop yields increases taking into account the projected trends in cl

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Season effects on the composition of milk produced by a Holstein herd managed under semi-confinement followed by compost bedded dairy barn management

Here, we studied the composition of milk produced by a Holstein herd in the municipality of Nova Boa Vista, Rio Grande do Sul (RS), Brazil.The herd was first managed under a semi-confinement system and subsequently, in a compost bedded dairy barn system to facilitate animal management and, more importantly, family work.We monitored milk production

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The constitutional guarantee of the provision of local Social Services in Spain: a comparative regional study

This article outlines the public architecture of social services in Spain from the perspective of the constitutional guarantee of the provision of local social services.For this, the Spanish Constitution is analyzed, as well as the 17 laws of social Mirror Plates services corresponding to the different Autonomous Communities.It is therefore a compa

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